Chris Myers
SBOL Chair (2019–2023) · University of Colorado, Boulder
Publications and posts
Synthetic Biology Open Language Visual (SBOL Visual) Version 3.0
People who engineer biological organisms often find it useful to draw diagrams in order to communicate both the structure of the nucleic acid sequences that they are engineering and the functional relationships between sequence features and other molecular species. Some typical practices and conventions have begun to…
Synthetic Biology Open Language Visual (SBOL Visual) Version 2.3
People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species. Some typical practices and conventions have…
Genetic Circuit Dynamics: Hazard and Glitch Analysis
Multiple input changes can cause unwanted switching variations, or glitches, in the output of genetic combinational circuits. These glitches can have drastic effects if the output of the circuit causes irreversible changes within or with other cells such as a cascade of responses, apoptosis, or the release of a…
Synthetic Biology Open Language Visual (SBOL Visual) Version 2.2
People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species. Some typical practices and conventions have…
Extending SynBioHub's Functionality with Plugins
SynBioHub is a repository for synthetic genetic designs represented in the Synthetic Biology Open Language (SBOL). To integrate SynBioHub into more synthetic biology workflows, its data processing capabilities need to be expanded. To this end, a plugin interface has been developed. Plugins can be developed for data…
Synthetic biology open language (SBOL) version 3.0.0
Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. When designing a synthetic system, synthetic biologists need to exchange information about multiple types of molecules, the intended behavior of the system, and…
Synthetic biology open language visual (SBOL visual) version 2.2
People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species. Some typical practices and conventions have…
Communicating Structure and Function in Synthetic Biology Diagrams
Biological engineers often find it useful to communicate using diagrams. These diagrams can include information both about the structure of the nucleic acid sequences they are engineering and about the functional relationships between features of these sequences and/or other molecular species. A number of conventions…
Communicating Structure and Function in Synthetic Biology Diagrams
Biological engineers often find it useful to communicate using diagrams. These diagrams can include information both about the structure of the nucleic acid sequences they are engineering and about the functional relationships between features of these sequences and/or other molecular species. A number of conventions…
A Computational Workflow for the Automated Generation of Models of Genetic Designs
Computational models are essential to engineer predictable biological systems and to scale up this process for complex systems. Computational modeling often requires expert knowledge and data to build models. Clearly, manual creation of models is not scalable for large designs. Despite several automated model…
SBOL-OWL: An Ontological Approach for Formal and Semantic Representation of Synthetic Biology Information
Standard representation of data is key for the reproducibility of designs in synthetic biology. The Synthetic Biology Open Language (SBOL) has already emerged as a data standard to represent information about genetic circuits, and it is based on capturing data using graphs. The language provides the syntax using a free…
A Computational Workflow for the Automated Generation of Models of Genetic Designs
Computational models are essential to engineer predictable biological systems and to scale up this process for complex systems. Computational modeling often requires expert knowledge and data to build models. Clearly, manual creation of models is not scalable for large designs. Despite several automated model…
SBOL-OWL: An Ontological Approach for Formal and Semantic Representation of Synthetic Biology Information
Standard representation of data is key for the reproducibility of designs in synthetic biology. The Synthetic Biology Open Language (SBOL) has already emerged as a data standard to represent information about genetic circuits, and it is based on capturing data using graphs. The language provides the syntax using a free…
Specifications of Standards in Systems and Synthetic Biology: Status and Developments in 2019
This special issue of the Journal of Integrative Bioinformatics presents an overview of COMBINE standards and their latest specifications. The standards cover representation formats for computational modeling in synthetic and systems biology and include BioPAX, CellML, NeuroML, SBML, SBGN, SBOL and SED-ML. The articles…
Synthetic Biology Open Language (SBOL) Version 2.3
textlesssection class=\"abstract\"textgreatertextlessh2 class=\"abstractTitle text-title my-1\" id=\"d230e2\"textgreaterAbstracttextless/h2textgreatertextlessptextgreaterSynthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering…
Synthetic Biology Open Language Visual (SBOL Visual) Version 2.1
Abstract People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species . Some typical practices and…
Synthetic Biology Open Language (SBOL) Version 2.3
Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility.…
Synthetic Biology Open Language Visual (SBOL Visual) Version 2.1
People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species . Some typical practices and conventions have…
Synthetic Biology Open Language (SBOL) Version 2.1.0
textlesssection class=\"abstract\"textgreatertextlessh2 class=\"abstractTitle text-title my-1\" id=\"d807e2\"textgreaterSummarytextless/h2textgreatertextlessptextgreaterSynthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles…
Synthetic Biology Open Language (SBOL) Version 2.1.0
Synthetic biology builds upon the techniques and successes of genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems. The field still faces substantial challenges, including long development times, high rates of failure, and poor reproducibility.…
BBF RFC 108: Synthetic Biology Open Language (SBOL) Version 2.0.0
The Synthetic Biology Open Language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards.
BBF RFC 108: Synthetic Biology Open Language (SBOL) Version 2.0.0
The Synthetic Biology Open Language (SBOL) has been developed as a standard to support the specification and exchange of biological design information in synthetic biology, filling a need not satisfied by other pre-existing standards.
The Synthetic Biology Open Language
The design and construction of engineered organisms is an emerging new discipline called synthetic biology and holds considerable promise as a new technological platform. The design of biologically engineered systems is however nontrivial, requiring contributions from a wide array of disciplines. One particular issue…
The Synthetic Biology Open Language
The design and construction of engineered organisms is an emerging new discipline called synthetic biology and holds considerable promise as a new technological platform. The design of biologically engineered systems is however nontrivial, requiring contributions from a wide array of disciplines. One particular issue…
Title: Synthetic Biology Open Language (SBOL) Version 1.0.0
In this BioBricks Foundation Request for Comments (BBF RFC), we specify the Synthetic Biology Open Language (SBOL) Version 1.0.0 to enable the electronic exchange of information describing DNA components used in synthetic biology. We define: 1. the vocabulary, a set of preferred terms and 2. the core data…
Title: Synthetic Biology Open Language (SBOL) Version 1.0.0
In this BioBricks Foundation Request for Comments (BBF RFC), we specify the Synthetic Biology Open Language (SBOL) Version 1.0.0 to enable the electronic exchange of information describing DNA components used in synthetic biology. We define: 1. the vocabulary, a set of preferred terms and 2. the core data…